Septin Function inCandida albicansMorphogenesis

Septin Function in Candida albicans Morphogenesis□D

The septin proteins function in the formation of septa, mating projections, and spores in Saccharomyces cerevisiae, as well as in cell division and other processes in animal cells. Candida albicans septins were examined in this study for their roles in morphogenesis of this multimorphic, opportunistically pathogenic fungus, which can range from round budding yeast to elongated hyphae. C. albica...

Role of the Yeast Gin4p Protein Kinase in Septin Assembly and the Relationship between Septin Assembly and Septin Function

To identify septin-interacting proteins in Saccharomyces cerevisiae, we screened for mutations that are synthetically lethal with a cdc12 septin mutation. One of the genes identified was GIN4, which encodes a protein kinase related to Hsl1p/Nik1p and Ycl024Wp in S. cerevisiae and to Nim1p/Cdr1p and Cdr2p in Schizosaccharomyces pombe. The Gin4p kinase domain displayed a two-hybrid interaction wi...

Bni5p, a septin-interacting protein, is required for normal septin function and cytokinesis in Saccharomyces cerevisiae.

In the budding yeast Saccharomyces cerevisiae, the Cdc3p, Cdc10p, Cdc11p, Cdc12p, and Sep7p/Shs1p septins assemble early in the cell cycle in a ring that marks the future cytokinetic site. The septins appear to be major structural components of a set of filaments at the mother-bud neck and function as a scaffold for recruiting proteins involved in cytokinesis and other processes. We isolated a ...

Septin function in yeast model systems and pathogenic fungi.

Signaling Complex Regulates Septin Function and Dendrite Morphology

Published Ahead of Print 16 April 2012. 10.1128/MCB.06633-11. 2012, 32(13):2467. DOI: Mol. Cell. Biol. Sylvain Meloche, Matthias Gaestel and Alexey Kotlyarov Menon, Ruth Simon, Benjamin Turgeon, Stefan Britsch, Frank Brand, Stefanie Schumacher, Shashi Kant, Manoj B. Function and Dendrite Morphology 5 Signaling Complex Regulates Septin MAPK-Activated Protein Kinase − [MAPK6]) (Mitogen-Activated ...